Proprietà chimiche della carbossimetilcellulosa

Cellulose derivatives with carboxymethyl substituents are prepared by treating cellulose with sodium hydroxide to form alkali cellulose, and then reacting with monochloroacetic acid. The glucose unit that constitutes cellulose has three replaceable hydroxyl groups, so products with different degrees of substitution can be obtained. 1mmol of carboxymethyl is introduced into the solution of water and dilute acid per 1g of dry weight, but it can swell and be used for ion exchange chromatography. Carboxymethyl pKa is about 4 in pure water and about 3.5 in 0.5mol/L NaCl. It is a weak acidic cation exchanger and is usually used for the separation of neutral and basic proteins when pH>4. Più del 40 percento dei gruppi idrossilici sostituiti da carbossimetil può essere sciolto in acqua per formare una soluzione colloidale stabile ad alta viscosità.